Tsukamoto, S.; Tane, K.; Ohta, T.; Matsunaga, S.; Fusetani, N.; Van Soest, R. W. M. (2001). Four New Bioactive Pyrrole-Derived Alkaloids from the Marine Sponge Axinellabrevistyla. Journal of Natural Products. 64(12): 1576-1578.
Four new alkaloids (1-4) were isolated from the marine sponge Axinella brevistyla, and their structures were determined on the basis of spectroscopic analysis. The alkaloids 1-4 were antifungal against the yeast Saccharomyces cerevisiae at <1.0, <1.0, 30, and 100 µg/disk, respectively. Compounds 1-3 also exhibited cytotoxicity against L1210 cells with IC50 values of 1.1, 0.66, and 2.5 µg/mL, respectively.