TY  - JOUR
AB  - An investigation was conducted to identify the structures and bioactive properties of five compounds isolated from the Halichondrida sponges Amorphinopsis foetida and Axinyssa aplysinoides. All compounds possessed the spiro-axane sesquiterpene core and all were
substituted at C-2 with nitrogen containing functionality. The stereochemistry of one known compound has been revised to (2R,5R,10S)-2-formamido-6-axene (3). It exhibited mild selective solid tumor and mild antibacterial activity and was found from Axinyssa. A second known substance whose stereochemistry has also been revised, (2R,5R,10S) 2-isothiocyanato-6-axene (4) plus its undescribed diastereomer (5) were isolated from Amorphinopsis. Both sponges were the source of two new N-phenethyl-2-formamido-6-axene diastereomeric compounds 6 and 7. No solid tumor or antibacterial activity was found for 4–7.
A1  - Wegerski, C.J.
A1  - Sonnenschein, R.N.
A1  - Cabriales, F.
A1  - Valeriote, F.A.
A1  - Matainaho, T.
A1  - Crews, P.
DO  - 10.1016/j.tet.2006.08.070
JO  - Tetrahedron
IS  - 44
SP  - 10393
EP  - 10399
C1  - 62(44): 10393-10399
TI  - Stereochemical challenges in characterizing nitrogenous spiro-axane sesquiterpenes from the Indo-Pacific sponges <i>Amorphinopsis</i> and <i>Axinyssa</i>
UR  - https://marinespecies.org/porifera/porifera.php?p=sourcedetails&id=390076
VL  - 62
PY  - 2006
Y2  - 2026-04-18
ER  -