Oliveira, J.H.H.L.; Nascimento, A.M.; Kossiga, M.H.; Cavalcanti, B.C; Pessoa, C.O.; Moraes, M.O.; Macedo, M.L.; Ferreira, A.G; Hajdu, E.; Pinheiro, U.S.; Berlinck, R.G.S. (2007). Cytotoxic alkylpiperidine alkaloids from the Brazilian marine sponge Pachychalina alcaloidifera. Journal of Natural Products. 70 (4): 538-543.

425655

Oliveira, J.H.H.L.; Nascimento, A.M.; Kossiga, M.H.; Cavalcanti, B.C; Pessoa, C.O.; Moraes, M.O.; Macedo, M.L.; Ferreira, A.G; Hajdu, E.; Pinheiro, U.S.; Berlinck, R.G.S.

2007

70 (4): 538-543

Publication

Available for editors   [request]

Four bis-piperidine alkaloids, madangamine F (1), haliclonacyclamine F (2). and arenosclerins D (3) and E (4), have been isolated from the marine sponge Pachychalina alcaloidifera and have been identified by analysis of spectroscopic data. The alkaloids displayed cytotoxic activity against different cancer cell lines. These results support the hypothesis of a common biogenetic origin for the Haplosclerida bis-piperidine and bis-pyridine alkaloids.

Brazil
South Atlantic

Biochemistry

Porifera

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