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Gros, E.; Al-Mourabit, A.; Martin, M.-T.; Sorres, J.; Vacelet, J.; Frederich, M.; Aknin, M.; Kashman, Y.; Gauvin-Bialecki, A. (2014). Netamines H–N, Tricyclic Alkaloids from the Marine Sponge Biemna laboutei and their Antimalarial Activity. Journal of Natural Products. 77(4): 818-823.
425935
10.1021/np4009283 [view]
Gros, E.; Al-Mourabit, A.; Martin, M.-T.; Sorres, J.; Vacelet, J.; Frederich, M.; Aknin, M.; Kashman, Y.; Gauvin-Bialecki, A.
2014
Netamines H–N, Tricyclic Alkaloids from the Marine Sponge <i>Biemna laboutei</i> and their Antimalarial Activity
Journal of Natural Products
77(4): 818-823
Publication
Available for editors  PDF available [request]
Chemical examination of the CH2Cl2–MeOH (1:1) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H–N (1–7), along with the known netamine G and mirabilins A, C, and F. Their structures were elucidated by interpretation of 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. Netamine M (6) was found to be cytotoxic, with an IC50 value in the micromolar range, and netamine K (4) exhibited activity against Plasmodium falciparum with an IC50 value of 2.4 µM.
Tropical Indian Ocean and Red Sea
Biochemistry
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2022-03-18 17:13:53Z
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2024-05-21 13:31:46Z
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Biemna laboutei Hooper, 1996 (additional source)
Western and Northern Madagascar for Biemna laboutei Hooper, 1996 


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